Your sentence is the follows.
The arterial component of anticoagulant action is closely connected with large and perforant arteries which embolisation represents the usual cause of the local tissue ischemia. The main purposes of such therapy are the local thrombosis advancing prevention, facilitation of spontaneous embolus lisis as well as prevention of the early re-embolosation due to thrombus spread from the proximal artery part or heart.