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 dao2812

link 7.01.2015 22:51 
Subject: AUC dose experienced by the subject pharm.
A still further advantage of the compositions of the present invention is the linearity of the "AUC dose experienced by the subject " in comparison with the administered dose of buprenorphine.
The depot composition of claim 19 or claim 20 which, upon administration to said subject provides linearity (proportionality) of the "AUC dose" in comparison with the administered dose of buprenorphine

AUC-площадь под фарм кривой. Как понять AUC dose experienced by the subject

Заранее спасибо!

 гарпия

link 7.01.2015 23:59 
похоже, здесь речь идет о биодоступности
а то бывает влили килограмм, а биодоступность типа всего 20%

 dao2812

link 17.01.2015 23:11 
Еще контекст:

A still further advantage of the compositions of the present invention is the linearity of the AUC dose experienced by the subject in comparison with the administered dose of buprenorphine. This may be seen from Figure 6 and allows the physician to control the experienced dose directly by control of the administered dose in a linear relationship.

 dao2812

link 17.01.2015 23:20 
experienced dose и administered dose: в чем разница?

 Andy

link 18.01.2015 0:15 
dao2812, если на пальцах - доза, ощущаемая пациентом и введенная доза.

 

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